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Symbol
Name
ID 		Traf3ip2
TRAF3 interacting protein 2
MGI:2143599
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgE level
Cutaneous anergy
Hypereosinophilia
Abnormal B cell count
Abnormal proportion of CD4-positive T cells
Abnormal proportion of CD8-positive T cells
Abnormal natural killer cell count
Recurrent aphthous stomatitis
Blepharitis
Lymphadenopathy
Hepatitis
Recurrent urinary tract infections
Abnormality of the immune system
Seborrheic dermatitis
Chronic mucocutaneous candidiasis
Chronic oral candidiasis
Recurrent vulvovaginal candidiasis
Skin rash
Immunodeficiency
Chronic tinea infection
Candida esophagitis
Phaeohyphomycosis
Recurrent infections
Onychomycosis
Recurrent respiratory infections
Recurrent viral infections
Meningitis
Deep dermatophytosis
Disease(s) Associated with TRAF3IP2
chronic mucocutaneous candidiasis

Mouse Phenotypes
immune system phenotype
impaired macrophage chemotaxis
parotid gland inflammation
submandibular gland inflammation
stomatitis
lacrimal gland inflammation
enlarged spleen
increased spleen weight
spleen hyperplasia
increased immature B cell number
increased transitional stage B cell number
abnormal transitional stage B cell morphology
increased dendritic cell number
increased follicular B cell number
increased marginal zone B cell number
increased B cell number
abnormal spleen B cell corona morphology
impaired eosinophil recruitment
impaired neutrophil recruitment
increased IgE level
increased IgG1 level
increased IgG2c level
increased IgG level
increased immunoglobulin level
abnormal immune system morphology
enlarged lymph nodes
lymph node hyperplasia
enlarged cervical lymph nodes
enlarged submandibular lymph nodes
lymphoid hyperplasia
abnormal immune system physiology
abnormal cytokine secretion
decreased interleukin-6 secretion
decreased susceptibility to autoimmune disorder
increased autoantibody level
increased anti-nuclear antigen antibody level
increased anti-chromatin antibody level
increased anti-double stranded DNA antibody level
increased anti-histone antibody level
increased anti-single stranded DNA antibody level
decreased inflammatory response
increased inflammatory response
blepharitis
kidney inflammation
glomerulonephritis
respiratory system inflammation
dermatitis
Availability Mouse Genotype
Traf3ip2adjm/Traf3ip2adjm
Traf3ip2Gt(IST11484G7)Tigm/Traf3ip2Gt(IST11484G7)Tigm *
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix *!
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Traf3ip2tm1Lix/Traf3ip2tm1.1Lix
Tg(CD19-cre/ERT2)1Cgn/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory